Featured publications
Logsdon GA, et al. The structure, function and evolution of a complete human chromosome 8. Nature.
2021 April 7. PDF
Logsdon GA and Eichler EE. Mining the gaps of chromosome 8. Nature.
2021 May 14.. PDF
Logsdon GA, Vollger MR, and Eichler EE. Long-read human genome sequencing and its applications. Nat Rev Gen. 2020 June 5.. PDF
Vollger MR*, Logsdon GA*, et al.
Improved assembly and variant detection of a haploid human genome using single-molecule, high-fidelity long reads.. Ann Hum Genet. 2019 November 11. PDF
*Authors contributed equally to the work
Logsdon GA, et al. Human artificial chromosomes that bypass centromeric DNA. Cell.
2019 July 25. PDF
Logsdon GA, et al. Both tails and the centromere targeting domain of CENP-A are required for centromere establishment. J Cell Biol.
2015 March 2. PDF
Featured preprints
Altemose N, Logsdon GA, et al. Complete genomic and epigenetic maps of human centromeres. bioRxiv. 2021 July 13. PDF
Nurk S, . . . , Logsdon GA, et al. The complete sequence of a human genome. bioRxiv. 2021 May 27. PDF
Giannuzzi G, Logsdon GA, et al. Alpha satellite insertions and the evolutionary landscape of centromeres. bioRxiv.
2021 May 6. PDF
Complete list of published work & preprints
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Altemose N, Logsdon GA, Bzikadze AV, Sidhwani P, Langley SA, Caldas GV, Hoyt SH, Uralsky L, Ryabov FD, Shew CJ, …, Eichler EE, Phillippy AM, Timp W, Dennis MY, O’Neill RJ, Schatz MC, Pevzner PA, Diekhans M, Langley CH, Alexandrov IA, Miga KH. Complete genomic and epigenetic maps of human centromeres. bioRxiv. 2021 July 13. doi: 10.1101/2021.07.12.452052
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McCartney AM, Shafin K, Alonge M, Bzikadze AV, Formenti G, Fungtammasan A, Howe K, Jain C, Koren S, Logsdon GA, Miga KH, Mikheenko A, Paten B, Shumate A, Soto DC, Sović I, Wood JMD, Zook JM, Phillippy AM, Rhie A. Chasing perfection: validation and polishing strategies for telomere-to-telomere genome assemblies. bioRxiv. 2021 July 2. doi: 10.1101/2021.07.02.450803
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Nurk S, Koren S, Rhie A, Rautiainen M, Bzikadze AV, Mikheenko A, Vollger MR, Altemose N, Uralsky L, Gershman A, Aganezov S, Hoyt SJ, Diekhans M, Logsdon GA, …, Eichler EE, Miga KH, Phillippy AM. The complete sequence of a human genome. bioRxiv. 2021 May 27. doi: 10.1101/2021.05.26.445798
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Gershman A, Sauria M, Hook PW, Hoyt SJ, Razaghi R, Koren S, Altemose N, Caldas GV, Vollger MR, Logsdon GA, Rhie A, Eichler EE, Schatz MA, O’Neill R, Phillippy AM, Miga KH, Timp W. Epigenetic patterns in a complete human genome. bioRxiv. 2021 May 27. doi: 10.1101/2021.05.26.443420
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Giannuzzi G, Logsdon GA, Chatron N, Miller DE, Reversat DE, Munson KM, Hoekzema K, Bonnet-Dupeyron M-N, Pierre-Antoine RF, Baker CA, Sanlaville D, Eichler EE, Schluth-Bolard Caroline, Reymond A. Alpha satellite insertions and the evolutionary landscape of centromeres. bioRxiv Accepted 2021 May 6. doi: 10.1101/2021.03.10.434819
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Logsdon GA, Vollger MR, Hsieh P, Mao Y, Liskovykh MA, Koren S, Nurk S, Mercuri L, Dishuck PC, Rhie A, …, Miga KH, Phillippy AM, Eichler EE. The structure, function and evolution of a complete human chromosome 8. Nature. 2021 April 7. doi: 10.1038/s41586-021-03420-7
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Nurk S, Walenz BP, Rhie A, Vollger MR, Logsdon GA, Grothe R, Miga KH, Eichler EE, Phillippy AM, Koren S. HiCanu: accurate assembly of segmental duplications and allelic variants from high-fidelity long reads. Genome Res. 2020 August 14. doi: 10.1101/gr.263566.120
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Miga KH, Koren S, Rhie A, Vollger MR, Gershman A, Bzikadze A, Brooks S, Howe E, Porubsky D, Logsdon GA, . . ., Eichler EE, Phillippy AM. Telomere-to-telomere assembly of a complete human X chromosome. Nature. 2020 July 14. doi: 10.1038/s41586-020-2547-7
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Vollger MR*, Logsdon GA*, Audanao PA, Sulovari A, Porubsky D, Peluso P, Wenger AM, Concepcion GT, Kronenberg ZN, Munson KM, Baker C, Sanders AD, Spierings DCJ, Lansdorp PM, Surti U, Hunkapiller MW, Eichler EE. Improved assembly and variant detection of a haploid human genome using single-molecule, high-fidelity long reads. Ann Hum Genet. 2019 November 11. doi: 10.1111/ahg.12364
*Authors contributed equally to the work
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Sulovari, A, Li R, Audano PA, Porubsky D, Vollger MR, Logsdon GA, Human Genome Structural Variation Consortium, Warren WC, Pollen AA, Chaisson M, Eichler EE. Human-specific tandem repeat expansion and differential gene expression during primate evolution. PNAS. 2019 October 28. doi: 10.1073/pnas.1912175116
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Logsdon GA, Gambogi CW, Liskovykh MA, Barrey EJ, Larionov V, Miga KH, Heun P, Black BE. Human artificial chromosomes that bypass centromeric DNA. Cell. 2019 July 25. doi: 10.1016/j.cell.2019.06.006
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Barra V, Logsdon GA, Scelfo A, Hoffman S, Hervé S, Aslanian A, Nechemia-Arbely Y, Cleveland DW, Black BE, Fachinetti D. Phosphorylation of CENP-A on serine 7 does not control centromere function. Nat Commun. 2019 Jan 11. doi: 10.1038/s41467-018-08073-1
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Wanat JJ, Logsdon GA, Driskill JH, Deng Z, Lieberman PM, Johnson FB. TERRA and the histone methyltransferase Dot1 cooperate to regulate replicative senescence in budding yeast. PLoS One. 2018 April 12. doi: 10.1371/journal.pone.0195698
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Guo LY, Allu PK, Zandarashvili L, McKinley KL, Sekulic N, Dawicki-McKenna JM, Fachinetti D, Logsdon GA, Jamiolkowski RM, Cleveland DW, Cheeseman IM, Black BE. Centromere maintenance is achieved by fastening CENP-A to DNA and directing an arginine anchor-dependent nucleosome structural transition. Nat Commun. 2017 June 9. doi: 10.1038/ncomms15775
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Fachinetti D*, Logsdon GA*, Abdullah A, Selzer EB, Cleveland DW, Black BE. CENP-A modifications on Ser68 and Lys124 are dispensable for establishment, maintenance, and long-term function of human centromeres. Dev Cell. 2017 January 9. doi: 10.1016/j.devcel.2016.12.014
*Authors contributed equally to the work
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Falk SJ, Guo LY, Sekulic N, Smoak EM, Mani T, Logsdon GA, Gupta K, Jansen LET, Van Duyne GD, Vinogradov SA, Lampson MA, Black BE. CENP-C reshapes and stabilizes CENP-A nucleosomes at the centromere. Science. 2015 May 8. doi: 10.1126/science.1259308
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Logsdon GA, Barrey EJ, Bassett EA, DeNizio JE, Guo LY, Panchenko T, Dawicki-McKenna JM, Heun P, Black BE. Both tails and the centromere targeting domain of CENP-A are required for centromere establishment. J Cell Biol. 2015 March 2. doi: 10.1083/jcb.201412011